Regulation of the segmentation gene fushi tarazu has been functionally conserved in Drosophila.
AUTOR(ES)
Maier, D
RESUMO
An evolutionary approach was applied to identify elements involved in the regulation of the segmentation gene fushi tarazu (ftz) by comparing the Drosophila melanogaster ftz gene with its Drosophila hydei homologue. The overall organization of the ftz gene is very similar in both species. Surprisingly, ftz proved to be inverted in the ANT-C of D. hydei with respect to D. melanogaster. Strong homologies extend over the entire 6 kb of the ftz upstream region with the best match in the 'upstream element'. We identified several highly conserved boxes embedded in unrelated sequences that correspond extremely well to two germ layer specific enhancers in the upstream element. Transformation experiments revealed that D. hydei ftz gene products can restore D. melanogaster ftz function and, furthermore, that trans-acting factors from D. melanogaster recognize and control D. hydei ftz regulatory elements. These findings indicate a conservation of the entire regulatory network among segmentation genes for several millions of years during the evolution of Drosophila.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=552166Documentos Relacionados
- Repression of the Drosophila fushi tarazu (ftz) segmentation gene.
- The beetle Tribolium castaneum has a fushi tarazu homolog expressed in stripes during segmentation.
- Drosophila 5-HT2 serotonin receptor: coexpression with fushi-tarazu during segmentation.
- Genetic Characterization of the Homeodomain-Independent Activity of the Drosophila Fushi Tarazu Gene Product
- Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.