REGULATION OF TASTE ACUITY BY THIOLS AND METAL IONS
AUTOR(ES)
Henkin, R. I.
RESUMO
The administration of thiol-containing drugs decreases taste acuity in man and animals. Copper (II) and zine (II) administration returns taste acuity to normal levels. The results suggest that (1) thiols and metals are in dynamic equilibrium in the metabolic net, (2) regulation of taste acuity occurs through changes which thiols and/or metals bring about in the conformation of a protein which lines the pore of the taste receptor and its membrane, and (3) thiols normally play an inhibitory role in taste.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285950Documentos Relacionados
- Coordinate regulation of Bacillus subtilis peroxide stress genes by hydrogen peroxide and metal ions.
- Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols.
- Exposure of actin thiols by the removal of tightly held calcium ions.
- Regulation of the L-lactase dehydrogenase from Lactobacillus casei by fructose-1,6-diphosphate and metal ions.
- A taste of metal and a smell of burning flesh