Regulation of proline oxidase activity by lactate.

AUTOR(ES)

Kowaloff, E M

RESUMO

We found that proline oxidase, the first enzyme of the proline degradative pathway, is inhibited by lactate. The Km of the enzyme for proline increases with increasing concentrations of lactate. Since proline can be a source for gluconeogenesis, regulation of proline degradation by lactate may serve as a mechanism for allocation of metabolic fuel sources. The marked inhibition of proline oxidase at levels of lactate that commonly occur in both genetic and acquired lactic acidosis may cause the previously unexplained hyperprolinemia seen in these metabolic disorders.

Documentos Relacionados

• Regulation of gonococcal sialyltransferase, lipooligosaccharide, and serum resistance by glucose, pyruvate, and lactate.
• Diagnosis of coronary artery disease by estimation of coronary sinus lactate.
• Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate.
• Sugar-glycerol cofermentations in lactobacilli: the fate of lactate.
• Regulation of Alternative Oxidase Activity by Pyruvate in Soybean Mitochondria.