Regulation of insulin mRNA abundance and adenylation: dependence on hormones and matrix substrata.
AUTOR(ES)
Muschel, R
RESUMO
The insulin mRNA levels of rat insulinoma cell lines increased six- to eightfold, and the cells entered a transient state of growth arrest when they were cultured in serum-free, hormonally defined medium and on an extract of extracellular matrix derived from a basement membrane-secreting tumor line, EHS. Insulinoma cultures in growth arrest responded to glucose with a two- to threefold increase in insulin secretion associated with an insulin mRNA that contained a poly(A) tail that was 120 to 140 bases longer than normal.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=367517Documentos Relacionados
- Phytochrome Regulation of Greening in Barley 1: Effects on mRNA Abundance and on Transcriptional Activity of Isolated Nuclei
- Regulation of mRNA abundance in activated T lymphocytes: identification of mRNA species affected by the inhibition of protein synthesis.
- Redox Regulation of Light-Harvesting Complex II and cab mRNA Abundance in Dunaliella salina.
- The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance.
- Higher plant Ca(2+)-ATPase: primary structure and regulation of mRNA abundance by salt.