Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver.

AUTOR(ES)

Goyette, M

RESUMO

We examined the transcription of six cellular oncogenes during the process of compensatory growth in rat liver after partial hepatectomy. We have previously reported that transcripts of c-rasH are elevated during regenerative growth of the liver. We now report that transcripts of c-rasK and c-myc genes are significantly elevated after partial hepatectomy, whereas transcripts of c-abl and c-src are essentially unchanged and transcripts of c-mos are undetectable in either normal or regenerating rat liver. In liver regeneration after partial hepatectomy or chemical injury, changes in c-myc transcripts occur before DNA synthesis. The elevation of c-myc and c-ras transcripts is sequential in that highest levels of c-myc transcripts were detected 12 to 18 h after partial hepatectomy, whereas the levels of c-rasH and c-rasK were maximal by 36 to 48 h. Transcripts of all three activated oncogenes returned to their basal levels by 96 h.

Documentos Relacionados

• Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis.
• Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors.
• Rsal polymorphism in c-Ki-ras
• Identification of an activated c-Ki-ras oncogene in rat liver tumors induced by aflatoxin B1.
• H-DNA and Z-DNA in the mouse c-Ki-ras promoter.