Regulação do gene gata3 humano pelo virus HTLVI
AUTOR(ES)
Simone Cristina Olenscki Gilli
DATA DE PUBLICAÇÃO
2004
RESUMO
The HTLV-I nonstructural protein Tax plays a crucial role in cellular transformation. It activates the transcription factors of various cellular genes and interacts with cellular proteins. Limited data are available on the interaction between specific T cell transcription factor GATA3 and Tax. hnplication for the significance ofGATA3 on T-cell development and function, (Th2) differentiation, and a role ofGATA3 during immune response has been reported. To determine the effect of the Tax protein on GATA3 gene expression, we investigated the interaction between this protein and the GATA3 promoter and repressor regions. The semi quantitative RT-PCR demonstrated a considerable decrease in the expression of the GATA 3 cDNA all subjects infected by HTLV I and no expression of GATA 3 mRNA was observed in one subject with ATLL and another with HAM/TSP. Results demonstrated an interaction between Tax and GATA3 gene and a role ofTax in the negative regulation of GATA3 expression, through its interaction with the repressor, ZEB. This interaction may be involved in the pathophysiology of adult T cell leukemiallymphoma and tropical spastic paraparesis/HTLV-I-associated myelophathy
ASSUNTO(S)
infecção linfoma - transmissão htlv (virus) fosfolipases
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=vtls000331107Documentos Relacionados
- GATA3 Is Selectively Expressed in the Trophectoderm of Peri-implantation Embryo and Directly Regulates Cdx2 Gene Expression*
- The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.
- A rare case of deafness and renal abnormalities in HDR syndrome caused by a de novo mutation in the GATA3 gene
- Critical Role for GATA3 in Mediating Tie2 Expression and Function in Large Vessel Endothelial Cells*
- Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3