Recurrence risks for neural tube defects in a genetic counseling clinic population.
AUTOR(ES)
Seller, M J
RESUMO
The recurrence of neural tube defects (NTD) in the sib following the index case of all patients who consulted the South-East Thames Regional Health Authority Genetics Centre in the period 1972 to mid-1979 was calculated. A total of 1037 consecutive patients was studied, of whom 958 (93%) were traced. The overall recurrence was 3.44% (1 in 29). However, if the index case was the first affected child in the family, the recurrence in the next sib was 3.15% (1 in 32), and if it was the second affected child, the recurrence was 11.76% (1 in 9). These figures give an indication of the actual recurrence among the 'selected' population who consult a genetic advice centre, and are somewhat, but not significantly, different from figures for the general NTD population, which have been derived from studies of whole families.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1048724Documentos Relacionados
- Recurrence risk after neural tube defects in a genetic counselling clinic.
- Recurrence risk of neural tube defects.
- Recurrence rates for neural tube defects and vitamin supplementation
- Season and interval for recurrence of neural tube defects.
- Neural tube malformations: complex segregation analysis and calculation of recurrence risks.
