Reconsidering targeted toxins to eliminate HIV infection: You gotta have HAART

AUTOR(ES)

Berger, Edward A.

FONTE

National Academy of Sciences

RESUMO

The success of highly active anti-retroviral therapy (HAART) has inspired new concepts for eliminating HIV from infected individuals. A major obstacle is the persistence of long-lived reservoirs of latently infected cells that might become activated at some time after cessation of therapy. We propose that, in the context of treatment strategies to deliberately activate and eliminate these reservoirs, hybrid toxins targeted to kill HIV-infected cells be reconsidered in combination with HAART. Such combinations might also prove valuable in protocols aimed at preventing mother-to-child transmission and establishment of infection immediately after exposure to HIV. We suggest experimental approaches in vitro and in animal models to test various issues related to safety and efficacy of this concept.

Documentos Relacionados

• Subacromial bursitis related to HIV infection: case report
• Could a simple surgical intervention eliminate HIV infection?
• IMMUNOLOGICAL ASPECTS OF AIRBORNE INFECTION: SOME GENERAL CONSIDERATIONS OF RESPONSE TO INHALATION OF TOXINS
• Randomised placebo controlled trials in HIV infection: to be or not to be?
• Beyond retrovirus infection: HIV meets gene therapy