Recombinant interleukin-6 protects mice against experimental bacterial infection.
AUTOR(ES)
Liu, Z
RESUMO
Because of reports of high levels of interleukin-6 (IL-6) in patients during infection, we studied the role of IL-6 in experimental infection. Mice infected with the facultative intracellular pathogen Listeria monocytogenes displayed high levels of IL-6 in their sera and tissues, particularly the spleen, 1 to 3 days after infection. At this time, the IL-6 titers correlated with bacterial numbers in individual mice and in groups of mice given graded doses of Listeria organisms. However, the presence of IL-6 in serum declined after 4 days, even when a large initial dose of bacteria meant that bacterial numbers were still increasing at this time. Recombinant mouse IL-6 injected intraperitoneally before infection protected mice in a dose-dependent manner. It was effective when given 4 h before infection but not when administration was delayed for 24 h postinfection. It is therefore believed that IL-6 plays a role in early priming of the immune response to infection. Its exact function in this model is being investigated.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=257478Documentos Relacionados
- Interleukin-6 induced at mucosal surfaces by gram-negative bacterial infection.
- The cellular source of interleukin-6 during Listeria infection.
- A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.
- Lipid X protects mice against fatal Escherichia coli infection.
- Interleukin-10 protects neonatal mice from lethal group B streptococcal infection.