Reciprocal antimicrobial synergism between Escherichia coli and Bacteroides fragilis in the presence of metronidazole.

AUTOR(ES)

Soriano, F

RESUMO

We have studied the antimicrobial action of metronidazole against Bacteroides fragilis and Escherichia coli both in pure cultures and in combination. Concentrations of metronidazole above the minimal inhibitory concentration (MIC) produced a marked bactericidal effect on B fragilis at six hours. E coli however showed only a slight and transitory decrease in population when exposed to concentrations of metronidazole close to its MIC. Kinetic studies of this drug's effect on mixed cultures of both organisms showed mutual bactericidal synergy between E coli and metronidazole against B fragilis and between B fragilis and metronidazole against E coli. These in vitro findings agree with the results obtained in vivo by other authors.

Documentos Relacionados

• Synergism between penicillin, clindamycin, or metronidazole and gentamicin against species of the Bacteroides melaninogenicus and Bacteroides fragilis groups.
• Potentially synergistic antimicrobial combinations with metronidazole against Bacteroides fragilis.
• Killing of Escherichia coli by human polymorphonuclear leucocytes in the presence of Bacteroides fragilis.
• Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole.
• Bactericidal activity of metronidazole against Bacteroides fragilis