Receptors for IgA on a subpopulation of human B lymphocytes.
AUTOR(ES)
Gupta, S
RESUMO
Human B lymphocytes from peripheral blood and tonsils and leukemic B cells from patients with chronic lymphocytic leukemia (CLL) were examined for the presence of receptors for IgA. Receptors for IgA were present on 5-20% of B cells from peripheral blood of normal persons, 6-21% of B cells from tonsils removed because of chronic enlargement, and 4-10% of B cells from patients with CLL. Prior incubation of B lymphocytes in medium containing fetal calf serum was normally essential for expression of receptors for IgA. IgM and IgG receptors were also examined on B cells from tonsils and CLL. Receptors for IgM were present on a large proportion of B cells from tonsils and B cells from patients with CLL. Their detection also required incubation of B cells in medium containing fetal calf serum for 2-3 days. In one patient with CLL, IgM receptors were present on only a small proportion of B cells. No significant change in IgG receptors on B cells from tonsils or CLL was observed when freshly isolated B cells and cultured receptors on B cells progressively decreased as a consequence of shedding of free Fc receptors into the supernates.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=383969Documentos Relacionados
- Switch recombination in normal IgA1+ B lymphocytes.
- Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.
- Subpopulations of human peripheral granulocyes and monocytes express receptors for IgA.
- Differential Susceptibility of Human IgA Immunoglobulins to Streptococcal IgA Protease
- Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.