Ras plasma membrane signalling platforms
AUTOR(ES)
Hancock, John F.
FONTE
Portland Press Ltd.
RESUMO
The plasma membrane is a complex, dynamic structure that provides platforms for the assembly of many signal transduction pathways. These platforms have the capacity to impose an additional level of regulation on cell signalling networks. In this review, we will consider specifically how Ras proteins interact with the plasma membrane. The focus will be on recent studies that provide novel spatial and dynamic insights into the micro-environments that different Ras proteins utilize for signal transduction. We will correlate these recent studies suggesting Ras proteins might operate within a heterogeneous plasma membrane with earlier biochemical work on Ras signal transduction.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1184533Documentos Relacionados
- H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway
- Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function.
- Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.
- Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane
- The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation