Rapidly fatal pulmonary fibrosis: the accelerated variant of interstitial pneumonitis.
AUTOR(ES)
Pratt, D S
RESUMO
We sought to explore immunological factors in patients who died with rapidly fatal fibrosing lung diseases (Hamman-Rich syndrome). A retrospective review of cases of interstitial lung disease showed 12 recent deaths from Hamman-Rich syndrome. The mean age was 62, men outnumbering women 3 : 1. Five patients had proved collagen vascular disease (rheumatoid arthritis three, lupus two). Four others had a history of allergic disorders, syphilis, chronic eosinophilia, or hypersensitivity reactions. One patient showed disappearance of immunofluorescence as fibrosis advanced, which has not previously been reported. The study suggests a possible aetiological link between disorders of immunity and Hamman-Rich syndrome. The evidence also supports the notion that Hamman-Rich syndrome is an accelerated variant of the more indolent interstitial pneumonias.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=471130Documentos Relacionados
- Tocainide-associated interstitial pneumonitis.
- Pulmonary cell populations in recipients of bone marrow transplants with interstitial pneumonitis.
- Morphology and pathogenesis of desquamative interstitial pneumonitis.
- Phenotypes of infiltrating cells in trehalose dimycolate-induced interstitial pneumonitis.
- Renal interstitial fibrosis: Remembrance of things past?
