Rapid and Efficient Uncatalyzed Knoevenagel Condensations from Binary Mixture of Ethanol and Water
AUTOR(ES)
Ferreira, João M. G. O., Resende Filho, João B. M. de, Batista, Poliane K., Teotonio, Ercules E. S., Vale, Juliana A.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2018-07
RESUMO
This paper presents a new green protocol for Knoevenagel condensations of aldehydes and compounds with an active methylene group in a binary mixture of ethanol/water (3:7, v/v). This medium favored the uncatalyzed Knoevenagel reactions and easy workup products can be obtained by precipitation in this medium and showed good isolated yields (55-100%) in short reaction times (1-60 min).
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