(R)-mevalonate excretion in human and rat urines.

AUTOR(ES)

Kopito, R R

RESUMO

(R)-Mevalonate was identified by radioenzymatic assay in human and rat urines. This was confirmed by spectrophotometric enzymatic assay of an ether extract of human urine. The average excretion rate of (R)-mevalonate in humans was 1.7 mumol/24 hr which corresponds to 29% of the glomerular filtration rate. In anesthetized rats the average rate of (R)-mevalonate excretion was 350 pmol/min, corresponding to 44% of the glomerular filtration rate. These rates were not affected by the sex of the subjects or animals. After bilateral nephrectomy, the concentration of (R)-mevalonate in rat serum increased within 2 hr to a new level that was 5 times that of sham-operated controls. Nephrectomized rats showed a decrease in their tolerance to an intravenous load of mevalonate. These data show that (R)-mevalonate is normally excreted in the urine of humans and rats. Urinary excretion of (R)-mevalonate should therefore be taken into account in in vivo studies on the metabolism of this compound.

Documentos Relacionados

• The Automicrobic System for urines.
• Screening by negative chemical ionization mass spectrometry for environmental contamination with toxic residues: Application to human urines.
• Mevalonate availability affects human and rat resistance vessel function.
• Sex difference in human mevalonate metabolism.
• BACTERIOPHAGY IN URINARY INFECTION PART I. THE INCIDENCE OF BACTERIOPHAGE AND OF BACILLUS COLI SUSCEPTIBLE TO DISSOLUTION BY THE BACTERIOPHAGE IN URINES. PRESENTATION OF CASES OF RENAL INFECTION IN WHICH BACTERIOPHAGE WAS USED THERAPEUTICALLY1