Quantificação de células endoteliais circulantes em portadores assintomáticos do vírus linfotrópico humano de células T do tipo 1 (HTLV1) por citometria de fluxo / Quantification of circulating endothelial cells in human T cell lymphotropic virus type 1 (HTLV1) asymptomatic carriers by flow cytometry

AUTOR(ES)

Ana Luísa Langanke Pedroso Meireles

DATA DE PUBLICAÇÃO

2009

RESUMO

Endothelial cells originated from the bone marrow (BM) take part in the physiopathology of several diseases which have vascular damage as a common factor. In spite of being a rare event, they are found in augmented quantity in the peripheral circulation of cancer patients. Evidence indicates that bone marrow-derived endothelial progenitor cells (CEPs) can contribute to tumor angiogenesis. Upon such a finding, circulating CEPs and mature endothelial cells (CEMs) have been researched as potential therapeutic targets and antiangiogenic drugs can be an option in anti-tumor therapy. Human T Cell Lymphotropic Virus Type 1 (HTLV1) carriers may develop diseases caused by the virus with high mortality rate, especially adult T-cell leukemia/lymphoma (ATL). The treatment for the symptomatic form of the disease remains disappointing. This cross-sectional study aimed at quantifying circulating endothelial cells in the blood of HTLV1 asymptomatic carriers in comparison to healthy individuals by flow cytometry. A sample of 30 individuals, HTLV1 carriers, age and sex paired, has been compared to the control group. Three patients were diagnosed with ATL, and deleted. HTLV1+ serology has been utilized as inclusion criteria, and negative for the remaining transfusion-transmittable diseases. CEPs values were greater in the asymptomatic carrier population (median: 0,8288 cells/mm 3 ) in relation to the control population (median: 0,4905 cells/mm 3 ; p = 0,035). There was no statistically significant difference in the quantification of CEMs and activated endothelial cells between asymptomatic carriers and the control group. This evidence suggest that there is angiogenic activity without neoplasic transformation, and the level of circulating endothelial progenitor cells can be used as biologic marker of disease activity and can reflect the antitumor efficacy of angiogenesis inhibitors

ASSUNTO(S)

flow cytometry endothelial cells leucemia-linfoma de células t do adulto virus linfotrópico de células t humanas tipo 1 leukemia-lymphoma adult t-cell neovascularização patológica células endoteliais citometria de fluxo neovascularization pathologic human t-lymphotropic virus 1

Documentos Relacionados

• Estrongiloidíase gástrica e infecção pelo vírus linfotrópico humano do tipo 1 de células T (HTLV-1)
• Lesões dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)
• Manifestações reumáticas associadas ao vírus linfotrópico humano de células T do tipo I (HTLV-I)
• Human T lymphotropic virus type 1 (HTLV-1) DNA proviral load quantification and immunological markets among healthy carries HTLV-1- associated myelopathy/tropical spastic paraparesis (TSP/HAM) patients.
• Mielopatia associada ao vírus linfotrópico humanode células T do tipo 1 (HTLV-1)