Psychiatric and clinical correlates of rapid cycling bipolar disorder: a cross-sectional study
Gigante, Alexandre D., Barenboim, Ivan Y., Dias, Rodrigo da S., Toniolo, Ricardo A., Mendonça, Tiago, Miranda-Scippa, Ângela, Kapczinski, Flávio, Lafer, Beny
Rev. Bras. Psiquiatr.
DATA DE PUBLICAÇÃO
Objective: Rapid cycling (RC) is a feature of bipolar disorder (BD) that has been associated with worse outcome and more severe disability. Our goal was to investigate the association of demographic and clinical factors with RC. Methods: We compared RC and non-rapid cycling (NRC) BD patients from the Brazilian Research Network in Bipolar Disorder (BRN-BD) regarding age at onset of BD; total number of episodes; previous number of manic, depressive, mixed, and hypomanic episodes; polarity of the first episode; gender; number of suicide attempts; number of lifetime hospitalizations and lifetime history of at least one hospitalization; family history of mood disorder; clinical comorbidities such as hypothyroidism, hyperthyroidism, seizures; and current use of medications such as lithium, anticonvulsants, antipsychotics, and antidepressants. Results: We studied 577 patients and found that 100 (17.3%) met the criteria for RC in the year before the investigation. RC patients had earlier age at onset, longer duration of disease, more lifetime depressive and manic episodes, higher number of suicide attempts, and higher rate antidepressant use. Conclusion: The presence of RC in the previous year was associated with specific clinical characteristics closely related to worse outcome in the course of BD.
- Impact of metabolic syndrome and clinical features on functioning in patients with bipolar disorder: a cross-sectional study
- Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: an empirical cross-sectional study
- Cardiovascular risk factors and major depressive disorder: a cross-sectional study in São Paulo, Brazil
- Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study
- Debriefing evaluation in nursing clinical simulation: a cross-sectional study