Proteomic Analysis of Azole Resistance in Candida albicans Clinical Isolates

AUTOR(ES)

Hooshdaran, Massoumeh Z.

FONTE

American Society for Microbiology

RESUMO

Changes in protein expression within a matched set of Candida albicans isolates representing the acquisition of azole resistance were examined by two-dimensional polyacrylamide gel electrophoresis and peptide mass fingerprinting. Proteins differentially expressed in association with azole resistance included Grp2p, Ifd1p, Ifd4p, Ifd5p, and Erg10p, a protein involved in the ergosterol biosynthesis pathway.

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