Protective effect of biological response modifiers on murine cytomegalovirus infection.
AUTOR(ES)
Ebihara, K
RESUMO
Pretreatment with two biological response modifiers (BRM), OK-432 and PS-K, protected mice from lethal infection by murine cytomegalovirus (MCMV). This was evidenced by an increase in 50% lethal doses and a decrease in titers of infectious viruses replicated in the liver and spleen. Spleen cells from the BRM-treated mice augmented the natural killer (NK) cell activity and suppressed the replication of MCMV in vitro. During MCMV infection, the NK cell activity of the spleen cells was maintained at a high level in the BRM-treated mice, whereas it was severely impaired in untreated mice. The BRM-induced protection was nullified by concomitant administration of antiasialo GM1 antibody. Interferon was neither induced by BRM treatment nor enhanced in BRM-pretreated and MCMV-infected mice. Thus, the protective effect of OK-432 and PS-K seems to be based on activation of NK cells and prevention of MCMV-induced inhibition of the NK cell activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254408Documentos Relacionados
- Protective effect of low-dose interferon against neonatal murine cytomegalovirus infection.
- Effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection.
- Protective effect of early serum from mice after cytomegalovirus infection.
- Effect of Ribavirin on Murine Cytomegalovirus Infection
- Alteration of host defense mechanisms by murine cytomegalovirus infection.
