Protection against hepatitis B by the Butang® recombinant vaccine in newborn children in South Brazil
AUTOR(ES)
Isolani, Aline Paula, Sversuti, Catia Silene, Sell, Ana Maria, Moliterno, Ricardo Alberto
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2006-08
RESUMO
The prevention of hepatitis B by vaccination is one of the most efficient tools to avoid the transmission of the virus. This study evaluated the immunogenicity of the national vaccine Butang® in children born in Campo Mourão City, state of Paraná, Brazil, aged 7 to 12 months, by determining the anti-HBsAg antibodies levels after completion of the National Immunization Program Protocol for hepatitis B. All 70 children evaluated by the MEIA method (immune-enzymatic micro particles) showed seroconversion to the Butang® vaccine. Nine children (12.9%) presented a low response, with anti-HBs titers between 11 and 100 mUI/ml; 39 children (55.7%) showed a good response to the vaccine, with titers between 101 and 1000 mUI/ml; and 22 children (31.4%) showed antibodies titers higher than 1000 mUI/ml. The mean titer of the anti-HBs antibody titers was 1408.1 ± 2870.26 mUI/ml (15.7 to 19560.0 mUI/ml). The levels of antibodies produced by the prematurely-born children were not statistically different from those found in the newborns. Fifty-five children were also evaluated through the ELFA method (ELISA with a final detection in fluorescence), which presented similar results. The results obtained in our study corroborated the effectiveness of the national vaccine Butang® in newborn children of Campo Mourão City, Paraná, even if they were premature.
Documentos Relacionados
- Seroepidemiology of hepatitis B virus infection and high rate of response to hepatitis B virus Butang®vaccine in adolescents from low income families in Central Brazil
- Immunogenicity of a Hepatitis B Recombinant Vaccine Produced by Intituto Butantan among Children in Rio de Janeiro.
- Vaccine Protection against Simian Immunodeficiency Virus by Recombinant Strains of Herpes Simplex Virus
- Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil
- Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia.