Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis
AUTOR(ES)
Rodrigues, Denise Silva, Salomão, Reinaldo, Kallas, Esper Georges
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2006-02
RESUMO
Three HIV-1-seronegative patients with disseminated tuberculosis presented significant depletion of T-cell counts, in CD4+ and/or CD8+ cells, associated with increased expression of activation marker CD38 on CD8+ T-lymphocytes. This finding raises the question of potential mechanisms involved in the activation or loss of T-cells in disseminated tuberculosis.
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