Production, characterization, and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens.
AUTOR(ES)
Rouse, D A
RESUMO
The incidence of Mycobacterium avium-Mycobacterium intracellulare complex infections has increased in recent years primarily because a significant proportion of acquired immunodeficiency syndrome patients develop disseminated M. avium complex disease. In an effort to develop new tools to study these infections, we have produced eight monoclonal antibodies directed against M. avium. Western blot (immunoblot) specificity analysis and protease sensitivity assays indicate that four of these antibodies recognize M. avium-specific protein epitopes and two react with M. avium complex-specific peptide determinants. These monoclonal antibodies may be useful clinically in the diagnosis of M. avium complex disease and in the laboratory for isolation and characterization of native and recombinant M. avium complex antigens.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=258645Documentos Relacionados
- Production, characterization, and species specificity of five monoclonal antibodies to Mycobacterium tuberculosis.
- Production, characterization, and protective effect of monoclonal antibodies to Clostridium chauvoei flagella.
- Monoclonal antibodies to the enterotoxin of Bacteroides fragilis: production, characterization, and immunodiagnostic application.
- Production and characterization of monoclonal antibodies against specific serotypes of Mycobacterium avium and the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex.
- Production, characterization, and application of monoclonal antibodies to Vibrio cholerae O139 synonym Bengal.
