Probability of Gene Fixation in an Expanding Finite Population

AUTOR(ES)

Kimura, Motoo

RESUMO

A mathematical theory was developed, based on diffusion models, that enables us to compute the probability of a rare mutant allele eventually spreading through a population when the population size changes with time. In particular, we elaborated the case in which the mutant allele has a definite selective advantage and the population expands following the logistic law. In this case, the probability of ultimate fixation of a single mutant is given by u = 2s(Z/N), where s is the selective advantage and Z/N is a factor by which the probability of fixation is modified through population expansion. Analytical expression was obtained for Z/N, and the validity of the formula for u was checked by Monte Carlo experiments.

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