Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway

AUTOR(ES)

De Zutter, Gerard S.

FONTE

The National Academy of Sciences

RESUMO

Neurotrophic factor deprivation causes apoptosis by a mechanism that requires macromolecular synthesis. This fact suggests that gene expression is necessary to achieve cell death. To identify mRNA that is expressed in apoptotic cells we used subtractive hybridization with cDNA prepared from neuronal pheochromocytoma cells. Monoamine oxidase (MAO) expression was increased in cells during nerve growth factor withdrawal-induced apoptosis. The increased apoptosis and induction of MAO was prevented by inhibition of the p38 mitogen-activated protein (MAP) kinase pathway. MAO may contribute to the apoptotic process because inhibition of MAO activity suppressed cell death. Together, these data indicate that MAO may be a target of pro-apoptotic signal transduction by the p38 MAP kinase pathway.

Documentos Relacionados

• MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
• A Conserved p38 Mitogen-Activated Protein Kinase Pathway Regulates Drosophila Immunity Gene Expression
• Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
• Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway
• Sea urchin deciliation induces thermoresistance and activates the p38 mitogen-activated protein kinase pathway