PRINTS and PRINTS-S shed light on protein ancestry

AUTOR(ES)

Attwood, T. K.

FONTE

Oxford University Press

RESUMO

The PRINTS database houses a collection of protein fingerprints. These may be used to make family and tentative functional assignments for uncharacterised sequences. The September 2001 release (version 32.0) includes 1600 fingerprints, encoding ∼10 000 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. In addition to its continued steady growth, we report here its use as a source of annotation in the InterPro resource, and the use of its relational cousin, PRINTS-S, to model relationships between families, including those beyond the reach of conventional sequence analysis approaches. The database is accessible for BLAST, fingerprint and text searches at http://www.bioinf.man.ac.uk/dbbrowser/PRINTS/.

Documentos Relacionados

• PRINTS-S: the database formerly known as PRINTS
• Pathologists shed new light on Sally Clark case
• Shed some (sun)light on vitamin D deficiency
• Rare genetic mutations shed light on the pathogenesis of Parkinson disease
• Single molecule spectroscopies and imaging techniques shed new light on the future of biophysics.