Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil
AUTOR(ES)
Medeiros, Luzidalva Barbosa de, Lacerda, Heloísa Ramos, Cavalcanti, Ana Maria Salustiano, Albuquerque, Maria de Fátima Pessoa Militão de
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2006-12
RESUMO
To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.
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