Prevalência de doença celíaca em mães de crianças com defeitos de fechamento do tubo neural no feto

AUTOR(ES)

Rodrigo Coutinho de Almeida

DATA DE PUBLICAÇÃO

2008

RESUMO

Introduction: Folic acid is one of the elements essential for the normal development of the fetus. Its deficiency during pregnancy can result in the appearance of neural tube closure defects (NTD). Celiac disease, characterized by intolerance to gluten, can result in poor absorption of nutrients potentially leading to deficiency of folic acid which could possibly result in a higher prevalence of NTD in celiac mothers offspring. Objective: To determine the prevalence of CD in a group of mothers of children affected by NTD. Methods: Mothers with children affected by NTD attending the walking in clinic of the Neuropediatric Surgical Unit of the Brasilia General Hospital, underwent antiendomysium serologic testing (IgA-EMA), utilizing the indirect immunofluorescence method on cryostat sections of monkey esophagus. Results: Two hundred-eight mothers, aged between 19 and 43 years (average: 33 years; median: 32 years) were tested. All mothers showed negative results on the EMA test. Conclusions: The negative results of the study suggest that celiac disease is not a risk factor for NTD in the offspring. Consequently, at this moment, routine screening for CD in pregnant women in order to avoid a possible pregnancy aggravated by NTD would not be justifiable.

ASSUNTO(S)

ciencias da saude celiac disease defeitos do tubo neural ácido fólico neural tube defects doença celíaca folic acid

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