Prevalência da doença celíaca em pacientes com síndrome de Turner




Background - Celiac disease is an immune mediated small intestinal enteropathy induced by gluten in genetically susceptible individuals. The prevalence of the celiac disease in the general population is approximately 0.3-1%. The high prevalence of celiac disease detected in Turner syndrome makes these patients a risk group for this condition. Celiac disease is associated with human leukocyte antigen alleles DQ2 and DQ8. Although this association has been well established in several countries, this is the first study to demonstrates this relation in Brazil. Objectives - To determine the prevalence of the celiac disease among Turner syndrome patients followed in a Brasilia general hospital and to determine the presence of predisponent human leukocyte antigen alleles in patients with positive serological results. Patients/methods - 56 patients with Turner syndrome were evaluated by two serological methods: antiendomysium and anti-tissue transglutaminase antibodies tests. Serologically positive subjects underwent small jejunal biopsy. The presence of DQ2 and DQ8 presisposing alleles was determined by polymerase chain reaction. Results The diagnosis of celiac disease was established in two patients (2/56) with positive serological markers and typical result on jejunal biopsy. (2/56). Both patients disclosed a DQ2 allele on polymerase chain reaction.The prevalence of celiac disease in study group was 3.6% (IC 95% = 0.8%- 6.4%). Conclusion - The data of this study endorse that the prevalence of the celiac disease among Turner patients is higher than in the general population. The DQ2 alleles of human leucocyte antigen confirm the genetic susceptibilities to disease.


cliac disease doença celíaca medicina síndrome de turner prevalence turner syndrome human leukocyte antigen serological screening triagem sorológica

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