Prevalence of white matter hyperintensities is not elevated in a large sample of adolescents and young adults with bipolar disorder
AUTOR(ES)
Mehrhof, Sara Z.; Popel, Najla; Mio, Megan; Lu, Weicong; Heyn, Chinthaka C.; Fiksenbaum, Lisa M.; MacIntosh, Bradley J.; Goldstein, Benjamin I.
FONTE
Braz. J. Psychiatry
DATA DE PUBLICAÇÃO
2021-04
RESUMO
Objective: The increased prevalence rate of white matter hyperintensities is one of the most consistently reported brain abnormalities in adults with bipolar disorder. However, findings in children and adolescents with bipolar disorder are less consistent. Prior studies have been constrained by small sample sizes and/or poor age- and sex-matching of healthy controls. We examined this topic in the largest sample of adolescents with bipolar disorder to date. Methods: T2-weighted 3-Tesla magnetic resonance imaging data were acquired for 83 adolescents with bipolar disorder diagnosed via the Kiddie Schedule for Affective Disorders and the Schizophrenia, Present and Lifetime version semi-structured interview and 64 age- and sex-matched healthy controls. All acquired scans were examined by neuroradiologists and the presence or absence of white matter hyperintensities was determined for each participant. Results: The prevalence of white matter hyperintensities did not differ between adolescents with bipolar disorder (13.3%) and controls (21.9%; χ2 = 1.90; p = 0.168). Conclusion: In contrast to the study hypothesis, the prevalence of white matter hyperintensities was not higher in adolescents with bipolar disorder than controls. The large sample size and good matching for age and sex bolster the reliability of this negative finding. Future studies are warranted to evaluate the prevalence, incidence, and predictors of white matter hyperintensities in early-onset bipolar disorder prospectively.
Documentos Relacionados
- Localization of Brain White Matter Hyperintensities and Urinary Incontinence in Community-Dwelling Older Adults
- Childhood trauma and bipolar spectrum: a population-based sample of young adults
- Multiple lesions in cerebral white matter in two young adults with thoracic extramedullary tumours.
- Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age‐related white matter hyperintensities: the LADIS Study
- Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder