Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil
AUTOR(ES)
Cruz, Márcio R, Cerqueira, Daniela M, Cruz, Waldenor B, Camara, Geni NL, Brígido, Marcelo M, Silva, Evandro O, Carvalho, Luciano GS, Martins, Cláudia RF
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2004-05
RESUMO
We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.
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