Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

AUTOR(ES)

Brenna, Sylvia Michelina Fernandes, Silva, Ismael Dale Cotrin Guerreiro da, Zeferino, Luiz Carlos, Pereira, Julia, Martinez, Edson Zachaione, Syrjänen, Kari Juhani

FONTE

Genetics and Molecular Biology

DATA DE PUBLICAÇÃO

2004

RESUMO

The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.

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