Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
AUTOR(ES)
Alencar, Marília Lage, Ortiz-Agostinho, Carmen Lucia, Nishitokukado, lêda, Damião, Adérson O.M.C., Abrantes-Lemos, Clarice P., Leite, André Zonetti de Arruda, Brito, Thales de, Chamone, Dalton de Alencar Fischer, Silva, Maria Elizabeth Rossi da, Giannella-Neto, Daniel, Sipahi, Aytan Miranda
FONTE
Clinics
DATA DE PUBLICAÇÃO
2012-09
RESUMO
OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil.
Documentos Relacionados
- Estudo da prevalência da doença celíaca em doadores de sangue na cidade de São Paulo
- Risk behavior disclosure among blood donors in Sao Paulo, Brazil
- Prevalence of Trypanosoma cruzi infection among Bolivian immigrants in the city of São Paulo, Brazil
- HIV prevalence among blood donors in a blood bank in Curitiba (Brazil)
- Decrease in hepatitis B prevalence among blood donors in Central-West Brazil