Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela

AUTOR(ES)

Rangel, Héctor Rafael, Garzaro, Domingo José, Torres, Jaime Rafael, Castro, Julio, Suarez, Jose Antonio, Naranjo, Laura, Ossenkopp, John, Martinez, Nahír, Gutierrez, Cristina, Pujol, Flor Helene

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2009-05

RESUMO

An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.

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