Prevalence of and risk factors for multidrug-resistant tuberculosis in Iran and its neighboring countries: systematic review and meta-analysis
AUTOR(ES)
Jimma, Worku, Ghazisaeedi, Marjan, Shahmoradi, Leila, Abdurahman, Ahmed Abdulahi, Kalhori, Sharareh Rostam Niakan, Nasehi, Mahshid, Yazdi, Sharifi, Safdari, Reza
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
2017-06
RESUMO
Abstract Tuberculosis, in particular drug-resistant tuberculosis, is of global concern due to the high mortality and morbidity associated with it annually. The aim of this study was to determine the prevalence of and the risk factors for multidrug-resistant tuberculosis in Iran and its neighboring countries. Four databases (PubMed, BioMed Central, EMBASE, and Web of Science) were searched using key terms. Nineteen eligible articles were identified, of which 12 and seven were used for quantitative and qualitative analysis, respectively. The overall pooled estimate of the prevalence of multidrug-resistant tuberculosis, including both new and previously treated tuberculosis cases, in Iran, Iraq, Turkey and Pakistan was 16% (95% confidence interval [CI] 11-20). The patients with a previous tuberculosis treatment history (odds ratio [OR] = 6.45; 95% CI 5.12-7.79), those aged <45 years (OR = 1.57; 95% CI 1.12-2.03), and those who were males (OR = 1.83; 95% CI 1.19-2.48) had an increased pool risk of developing multidrug-resistant tuberculosis. The forest plot revealed that the pooled odds for the development of multidrug- resistant tuberculosis were 2.01 (95% CI 1.65-2.36). Poor adherence to treatment was one of the predictors of unsuccessful treatment outcomes. Multidrug-resistant tuberculosis is a great concern for public health programs in many countries globally, including those included in this review. The risk factors for the development of multidrug-resistant tuberculosis, specifically a previous tuberculosis treatment history, should be targeted through the implementation of specialized interventions.
Documentos Relacionados
- Prevalence of malaria relapse: systematic review with meta-analysis
- Prevalence and risk factors of incidental prostate cancer in certain surgeries for benign prostatic hyperplasia: A systematic review and meta-analysis
- Multidrug-resistant tuberculosis
- Analysis of neonatal mortality risk factors in Brazil: a systematic review and meta-analysis of observational studies
- Hepatitis Delta Prevalence in South America: A Systematic Review and Meta-Analysis