Prevalence and covariation of protease inhibitor resistance related mutations of HIV type 1 subtype F / "Prevalência e covariação de mutações relacionadas à resistência aos inibidores de protease no subtipo F do HIV-1"

AUTOR(ES)

Marcia Perez Resende Oliveros

DATA DE PUBLICAÇÃO

2005

RESUMO

Each HIV-1 subtype has a specific mutation pattern. Data on HIV-1 antiretroviral resistance mutations were obtained with subtype B, the first in prevalence in Brazil. The second in some regions is subtype F. Mutation patterns of Brazilian subtype F protease sequences were analyzed and performed a research of the sequences of Stanford Database. The analysis of two groups of sequences (untreated and treated patients with protease inhibitors) showed 19 treatment associated mutations also common in subtype B and 17 combinations of statistically treatment associated mutations that were quite different to those described for subtype B, indicating the need of studies to evaluate specific mutation pathways of subtype F.

ASSUNTO(S)

polimorfismo (genÉtica) protease inhibitors polymorfism (genetics) prevalÊncia bases de dados mutation databases inibidores de protease hiv mutaÇÃo prevalence

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