Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
AUTOR(ES)
Andreazza, Itamar Francisco, Ferraz, Humberto Gomes
FONTE
Brazilian Archives of Biology and Technology
DATA DE PUBLICAÇÃO
2011-04
RESUMO
The aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name.
Documentos Relacionados
- Drug release from kollicoat SR 30D-coated nonpareil beads: Evaluation of coating level, plasticizer type, and curing condition
- Preparation of pellets containing Pothomorphe umbellata extracts by extrusion-spheronization: improvement of 4-nerolidylcatechol photostability
- Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process
- Development and in vitro evaluation of chitosan-Eudragit RS 30D composite wound dressings
- Technological development of Cecropia glaziovi extract pellets by extrusion-spheronization