Preparation and properties of liposome-associated gentamicin.
AUTOR(ES)
Morgan, J R
RESUMO
Gentamicin was successfully incorporated into neutral, anionic, and cationic liposomes, and the percentage of gentamicin incorporated was found to be a function of lipid concentration. Gentamicin did not leak out of the liposomes over a 3-week period at 4 degrees C. When liposome-associated gentamicin was administered intravenously to rabbits, its serum half-life was greatly prolonged. Intragastric administration of dipalmitoylphosphatidylcholine liposomes containing gentamicin resulted in the appearance of gentamicin in serum. Liposome-associated gentamicin, when administered intravenously, led to the appearance of gentamicin in the liver and spleen, which was not observed when rabbits were injected with free gentamicin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283829Documentos Relacionados
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