Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate
AUTOR(ES)
van Tonder, Elsa C
FONTE
Springer-Verlag
RESUMO
The purpose of the study was to characterize the physicochemical, structural, and spectral properties of the 1∶1 niclosamide and methanol, diethyl ether, dimethyl sulfoxide, N,N' dimethylformamide, and tetrahydrofuran solvates and the 2∶1 niclosamide and tetraethylene glycol hemisolvate prepared by recrystallization from these organic solvents. Structural, spectral, and thermal analysis results confirmed the presence of the solvents and differences in the structural properties of these solvates. In addition, differences in the activation energy of desolvation, batch solution calorimetry, and the aqueous solubility at 25°C, 24 hours, showed the stability of the solvates to be in the order: anhydrate > diethyl ether solvate > tetraethylene glycol hemisolvate > methanol solvate > dimethyl sulfoxide solvate > N,N' dimethylformamide solvate. The intrinsic and powder dissolution rates of the solvates were in the order: anhydrate > diethyl ether solvate > tetraethylene glycol hemisolvate > N,N' dimethylformamide solvate > methanol solvate > dimethyl sulfoxide solvate. Although these nonaqueous solvates had higher solubility and dissolution rates than the monohydrous forms, they were unstable in aqueous media and rapidly transformed to one of the monohydrous forms.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2784863Documentos Relacionados
- Preparation and Physicochemical, Structural and Morphological Characterization of Phosphorylated Starch
- Unilamellar vesicles as potential capreomycin sulfate carriers: Preparation and physicochemical characterization
- Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide
- Preparation and physicochemical and immunological characterization of polysaccharide-outer membrane protein complexes of Neisseria meningitidis.
- Rosettes from Friend leukemia virus envelope: preparation and physicochemical and partial biological characterization.