Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac
AUTOR(ES)
Piyakulawat, Pimwipha
FONTE
Springer-Verlag
RESUMO
The polyelectrolyte complex (PEC) hydrogel beads based on chitosan (CS) and carrageenan (CR) have been studied as a controlled release device to deliver sodium diclofenac (DFNa) in the simulated gastrointestinal condition. Various factors potentially influencing the drug release (ie, CS/CR proportion, DFNa content, types and amount of cross-linking agents) were also investigated. The optimal formulation was obtained with CS/CR proportion of 2/1 and 5% (wt/vol) DFNa. The controlled release of the drug from this formulation was superior to other formulations and was able to maintain the release for ∼8 hours. Upon cross-linking with glutaric acid and glutaraldehyde, the resulting beads were found to be more efficient for prolonged drug release than their non-cross-linking counterparts. The bead cross-linked with glutaraldehyde was able to control the release of the drug over 24 hours. The difference in the drug release behavior can be attributed to the differences in ionic interaction between the oppositely charged ions and to the concentrations of the drug within the beads, which depends on the compositions of the formulation and the pH of the dissolution medium. The release of drug was controlled by the mechanism of the dissolution of DFNa in the dissolution medium and the diffusion of DFNa through the hydrogel beads.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2750683Documentos Relacionados
- Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium
- Design and evaluation of matrix-based controlled release tablets of diclofenac sodium and chondroitin sulphate
- Evaluation of sodium diclofenac release using natural rubber latex as carrier
- Preparation and evaluation of chitosan beads immobilized with Iron(III) for the removal of As(III) and As(V) from water
- Comparison of different water/oil microemulsions containing diclofenac sodium: Preparation, characterization, release rate, and skin irritation studies