Preparation and antitubercular activity of lipophilic diamines and amino alcohols

AUTOR(ES)

OR Júnior, Celso, Le Hyaric, Mireille, Costa, Cristiane F da, Corrêa, Taís A, Taveira, Aline F, Araújo, Débora P, Reis, Elaine FC, Lourenço, Maria Cristina S, Vicente, Felipe RC, Almeida, Mauro V de

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2009-08

RESUMO

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.

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