Preparação e caracterização de uma mistura eutética baseada em um derivado de óleo essencial extraído do Syzygium aromaticum L. / Preparation and characterization of a eutectic mixture based in an essential oil derivative extracted from Syzygium aromaticum L.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

The Syzygium aromaticum L. plant produces the cloves buds which are dried. From these dried buds the essential oil is extracted. The major compound is eugenol. Some of eugenols pharmacological properties include fungicidal, bactericidal, anesthetic, and other activities. However, eugenol (EUG) was modified to eugenyl acetate (EA) by adding the acetate group to the bound hydroxyl. The modification was performed in order to eliminate the solubility problems which cause a difficult relationship with bioavailability. The solubility problem restrains its use in pharmaceutical formulations. A eutectic mixture was prepared using the eugenyl acetate as the principal active ingredient and a polyethyleneglycol 3350 (PEG) as the hydrophilic carrier. The phase diagram demonstrated that the eutectic mixture occurred with 80% EA and 20% PEG composition. The thermal characteristics at the eutectic point were 21.33°C for the peak temperature and 5.71Jg-1 for the energy of fusion. Thus, the rate of permeability and solubility of eugenyl acetate will be enhanced. This will contribute to an increase in its bioavailability, thus promoting its use in pharmaceutical formulations.

ASSUNTO(S)

acetato de eugenila eutético essential oil eugenyl acetate syzygium aromaticum syzygium aromaticum l. Óleo essencial eutectic

ACESSO AO ARTIGO

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