PREPARAÇÃO DE HIDRAZONA E N-ACILIDRAZONA USANDO FÁRMACOS COMERCIAIS COMO REAGENTES: AULAS PRÁTICAS DE SÍNTESE DE COMPOSTOS BIOATIVOS

AUTOR(ES)

Arruda, Isabella Elias; Macedo, Brendo Vinícius Santos; Macedo, Joseane da Conceição; Campos, Wesley Randson Alcantara; Araújo, Cleônia Roberta Melo; Gonsalves, Arlan de Assis

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2020-05

RESUMO

Several scientific works demonstrate the chemical and medicinal importance of hydrazone compounds. In this regard, the present paper proposes some practical classes of chemoinformatics and organic chemistry, using investigative and illustrative strategies, to teach the synthesis of a hydrazone and a N-acylhydrazone with proven biological activity. The motivating element used for the development of this didactic material was the use of commercial drugs, such as hydralazine and isoniazid, as alternative reagents for the synthesis of the target compounds. The sequence of experimental classes was planned to demonstrate the role of chemistry in the development of new drugs, to estimulate the curiosity of undergraduate students and to facilitate learning and the assimilation of the contents.

Documentos Relacionados

• Análise conformacional de derivados n-acilidrazona em solvente aquoso
• Teores de compostos bioativos em cafés torrados e moídos comerciais
• Determinação de compostos bioativos em amostras comerciais de café torrado
• N-halossacarinas: reagentes úteis (e alternativos) em síntese orgânica
• Preparação de compostos orgânicos aplicados a síntese eletroquímica de polímeros eletroluminescentes