Preliminary results on the effects of CD40/CD40L interactions and SAC-induction on IFN-gamma expression in human schistosomiasis

AUTOR(ES)

Montenegro, Silvia ML, Abath, Frederico GC, Domingues, Ana LC, Melo, Wlademir, Morais, Clarice NL de, Coutinho, Eridan M, Mahanty, Siddhartha, Wynn, Thomas

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2001-09

RESUMO

In this communication the authors analyzed the pattern of expression of IFN-gamma as a surrogate type 1 response in different clinical forms of schistosomiasis in response to stimulation involving T-cell dependent and T-cell independent pathways, to investigate which pathways were functional in human schistosomiasis, and to further characterize the nature of Th1 response impairment in this parasitic disease.

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