Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive.

AUTOR(ES)

Flood, J F

RESUMO

Immediate post-training, stereotactically guided, intraparenchymal administration of pregnenolone sulfate (PS) into the amygdala, septum, mammillary bodies, or caudate nucleus and of PS, dehydroepiandrosterone sulfate, and corticosterone into the hippocampus was performed in mice that had been weakly trained in a foot-shock active avoidance paradigm. Intrahippocampal injection of PS resulted in memory enhancement (ME) at a lower dose than was found with dehydroepiandrosterone sulfate and corticosterone. Intraamygdally administered PS was approximately 10(4) times more potent on a molar basis in producing ME than when PS was injected into the hippocampus and approximately 10(5) times more potent than when injected into the septum or mammillary bodies. ME did not occur on injection of PS into the caudate nucleus over the range of doses tested in the other brain structures. The finding that fewer than 150 molecules of PS significantly enhanced post-training memory processes when injected into the amygdala establishes PS as the most potent memory enhancer yet reported and the amygdala as the most sensitive brain region for ME by any substance yet tested.

Documentos Relacionados

• Post-Training Cyclooxygenase-2 (COX-2) Inhibition Impairs Memory Consolidation
• Memory enhancement induced by post-training intrabasolateral amygdala infusions of β-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala
• MUSCULOARTICULAR EVALUATION OF THE HYDROTHERAPY EFFECTS ON BASKETBALL PLAYERS POST-TRAINING RECOVERY
• Assessment of Effects of Pre- and Post-training Programme for Healthcare Professionals about Breastfeeding
• When Top-Down Meets Bottom-Up: Auditory Training Enhances Verbal Memory in Schizophrenia