Possible Mechanism of Decreased Susceptibility of Neisseria gonorrhoeae to Penicillin

AUTOR(ES)

Rodriguez, William

RESUMO

By use of 14C-labeled benzyl penicillin, it has been established that β-lactamases and/or acylases play no role in the resistance of Neisseria gonorrhoeae to penicillin. It has been found, however, that very susceptible strains of the organisms (minimal inhibitory concentration, 0.008 μg/ml) bind 10 to 15 times as much penicillin as do moderately to highly resistant strains of the gonoccoccus (minimal inhibitory concentration, 0.125 to 2.0 μg/ml). It is postulated that this degree of change in binding components of the whole cell and whole cytoplasmic membrane is sufficient to account for the decreased susceptibility of the organism to penicillin.

Documentos Relacionados

• Decreased Azithromycin Susceptibility of Neisseria gonorrhoeae Due to mtrR Mutations
• Neisseria meningitidis with decreased susceptibility to penicillin in Saskatchewan, Canada.
• Susceptibility to cephalosporins of penicillin-susceptible and penicillin-resistant strains of Neisseria gonorrhoeae from Philadelphia.
• Emergence in Italy of a Neisseria meningitidis Clone with Decreased Susceptibility to Penicillin
• Remarkable Increase in Central Japan in 2001-2002 of Neisseria gonorrhoeae Isolates with Decreased Susceptibility to Penicillin, Tetracycline, Oral Cephalosporins, and Fluoroquinolones