Positive genetic feedback governs cAMP spiral wave formation in Dictyostelium.
AUTOR(ES)
Levine, H
RESUMO
The aggregation stage of the life cycle of Dictyostelium discoideum is governed by the chemotactic response of individual amoebae to excitable waves of cAMP. We modeled this process through a recently introduced hybrid automata-continuum scheme and used computer simulation to unravel the role of specific components of this complex developmental process. Our results indicated an essential role for positive feedback between the cAMP signaling and the expression of the genes encoding the signal transduction and response machinery.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=39031Documentos Relacionados
- Two cAMP receptors activate common signaling pathways in Dictyostelium.
- Conditions that alter intracellular cAMP levels affect expression of the cAMP phosphodiesterase gene in Dictyostelium.
- G alpha 3 regulates the cAMP signaling system in Dictyostelium.
- Two-phase regulatory pathway controls cAMP receptor-mediated expression of early genes in Dictyostelium.
- Antagonistic effects of signal transduction by intracellular and extracellular cAMP on gene regulation in Dictyostelium.