Population dynamics of natural antibodies in normal and autoimmune individuals.
AUTOR(ES)
Varela, F
RESUMO
We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoire, regulating the activation and decay of individual clones. The temporal changes of both disease-specific and nonspecific autoantibodies are consistently modified in autoimmune individuals.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=51989Documentos Relacionados
- Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals.
- Comparison of three primitive reflexes in neurological patients and in normal individuals.
- Interferon messenger RNA is produced constitutively in the organs of normal individuals.
- A comparison of purposeless movements in psychiatric patients treated with antipsychotic drugs, and normal individuals.
- Anti-idiotypic antibodies against a human multiple organ-reactive autoantibody. Detection of idiotopes in normal individuals and patients with autoimmune diseases.