Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

AUTOR(ES)

Vicente, Anna Luiza Silva Almeida; Marqui, Alessandra Bernadete Trovó de; Gomes, Mariana Kefalas Oliveira; Assunção-Luiz, Alan Vinicius; Balarin, Marly Aparecida Spadotto; Tanaka, Sarah Cristina Sato Vaz; Resende, Elisabete Aparecida Mantovani Rodrigues de; Lima, Marco Fábio Prata; Cintra, Mariangela Torreglosa Ruiz

FONTE

Revista da Associação Médica Brasileira

DATA DE PUBLICAÇÃO

2022

RESUMO

SUMMARY OBJECTIVE: The polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested that these polymorphisms may be associated with the risk of polycystic ovary syndrome. This study aimed to investigate the association between rs2010963 and rs833061 polymorphisms and haplotypes of VEGF in the etiology of polycystic ovary syndrome. METHODS: A total of 210 women, 102 diagnosed with polycystic ovary syndrome and 108 controls, participated in this study. The genotyping of the samples was performed by PCR-RFLP and real-time PCR for rs2010963 and rs833061 polymorphisms, respectively. The statistical analyses were performed by the chi-square test and logistic regression model. RESULTS: The clinical characteristics of the patients showed that 75.8% of the patients did not become pregnant, 36.3% had a family history of polycystic ovary syndrome, 58.6% were obese, and about 60% had clinical characteristics of hyperandrogenism. There were no associations between the distribution of rs2010963 (OR 1.24; 95%CI 0.60–2.57; p=0.56) and rs833061 (OR 0.78; 95%CI 0.32–1.92; p=0.59) in patients and controls. CONCLUSIONS: The patients with polycystic ovary syndrome have similar rates of VEGF polymorphisms rs2010963 and rs833061 on the general population.

Documentos Relacionados

• VEGF gene rs35569394 polymorphism in patients with Polycystic Ovary Syndrome
• Polymorphisms of the GSTT1 and GSTM1 genes in polycystic ovary syndrome
• Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome
• Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?
• Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.