Poly(Inosinic Acid)·Poly(Cytidylic Acid) Inhibition of DNA Synthesis in Synchronized HeLa Cells
AUTOR(ES)
Teng, C. T.
RESUMO
Inhibition by double-stranded polyribonucleotides of DNA synthesis in synchronized HeLa cultures is dose- and time-dependent. Inhibition by poly(I·C) primarily affected late G1 and early S phases of the cell cycle. Single-stranded polynucleotides, native calf-thymus DNA, and yeast RNA had no effect. Radioautography showed that after 2-hr exposure the synthetic polyribonucleotides were predominantly inside the nucleus. The results extend the spectrum of action of double-stranded RNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=427354Documentos Relacionados
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