Poly(ethylene-co-methyl acrylate)/poly(caprolactone) triol blends for drug delivery systems: characterization and drug release
AUTOR(ES)
Kanis, Luiz A., Soldi, Valdir
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
Poly(ethylene-co-methyl acrylate) (EMA) and poly (caprolactone) triol (PCL-T) blends, a biodegradable aliphatic polyester with low molecular weight and moderate water solubility containing diltiazem hydrochloride (DZ) were studied in terms of the thermal and morphological properties, and drug release mechanism. An increase in the PCL-T content in the EMA/PCL-T/DZ films decreased the degree of DZ crystallinity. Drug release from these films is temperature-dependent, and it is possible to modify the drug release rate by adjusting the EMA/PCL-T composition of the blends. The mechanism of drug release is governed by PCL-T melting and PCL-T leaching from EMA matrix.
Documentos Relacionados
- Floating drug delivery systems: A review
- Therapeutic Systems: Pattern-Specific Drug Delivery: Concept and Development
- A Microrheological Study of Poly(Methyl Methacrylate) Elastomer/Poly(Ethylene Terephthalate) (PMMAelast/PET) Blends
- Preparation and characterization of poly (L-lactic acid) and poly(ethylene oxide) blends
- Nanoparticle-based drug delivery systems: promising approaches against infections